[Tofuboy]

Let's not bring it to conclusion on the drive shaft right away. It could be something simple before you spend a large amount of money.

threethirteen--Did you change anything on your wheels recently? Break pads? Rims? perhaps worn wheel bearing?

It could just be a simple bump or dent on the back of the rim that does not clear the clearance on your suspension.

Put the car on the lift and turn the wheel that is making the clicking noise to see where is the noise coming from, that should solve a lot of mystery.