does this issue occur when locking and unlocking the doors? my truck requires 2 clicks to unlock both doors. 1st click unlocks drivers side only so its possible to troubleshoot directly to the drivers side and not both sides.
i replaced a window motor in mine on the druivers side and had issues with the door locks doing the same thing afterwards, i found the bar that ran to the switch in the door got bent when reinstalling the door panel causing the actuator to bind which made it unable to move, it caused the fuse to blow, with the door panel removed it ceased to have the problem, upon fixing the rod i no longer had the problem.
its possible the solenoid is bound in position, or just no longer good. this would cause for a high draw of amps that would cause the fuse to blow. in order to check the solenoid take a multimeter set for ohms and compare the resistance of the actuator on the drivers side door with the one on the passenger side, they should be relativly close if one has extremely low resistance in comparison leave it unhooked and try operation of the door locks again. if you dont have a multimeter it is possible to leave one side unhooked and try to operate the door locks, the other side should work properly without blowing the fuse (repeat for oppsite side as necessary). in this instance inspect for binding or replace the one disconnected that did not work and caused the fuse to blow. repeat as necessary to discover which side is not working properly. if you unhook both solenoids it is possible to determine they are neither binding or shorting if the fuse still blows when they are disconnected, this would indicate a short in the electrical wiring of the vehicle ( a cut wire).