It sounds like a fun project.
Here are a few suggestions.
First of all, the stock rear end is not so bad. People have used some fairly decent engines with the stock rear and been okay. I think you should leave it in place.
Most weaker rear ends break when people strap in big V8's with sticky tires, then attempt wheel-lifting launches. The S2000 driveline simply is not going to launch that hard. By the time it reaches torque peak, the car will already be rolling nicely. Remember, the faster a gear set is rotating, the more power it can handle.
Also, swapping in another rear is a lot of work. The S10 rear would require custom-welded control arm mounts and, most likely, a new ring and pinion, since most come with relatively tall gearing, which is not too good for the high-revving Honda engine.
The chevette rear will likely have 4:11 gears, just right for the engine.
I think the rest of it will simply be loads of fabricating. It would help to start with a manual trans Chevette .You will likely have to adapt a hydraulic clutch master cylinder to the existing clutch pedal.
You will need a high-pressure in-line electric fuel pump with a pressure regulator, as well as the Honda ECM and wiring harness.
Hopefully, your Honda engine is a pre-2006 model, so the throttle linkage can be adapted, using a cable. Later ones used a drive-by-wire throttle, and would be more difficult to adapt.
Frankly, it sounds like fun, and will make a very interesting ride that the guys in Barrie will not believe!
But will be a lot of work. Post pics if you are going to do the project.
