done quite a few pumps on pickups....if you have about 3 other people and no heavy tool boxes in the bed, it ALOT easier(chainfall hoist should work with correct balancing in leiu of other people). with either way, you will get the mouthfull of rust/dirt. 8 bolts for the bed, and 2 plugs for wires, and a couple bolts at the filler neck. if you lift the bed off, make sure when stetting it on the bumper that you have that vertical brace/bar on the bumper....if not you may collapse the rear fenders/bed area.
this method is only my opinion, and when using said method, i am using a lift and air tools, so it makes it easier to pull the bed. good luck!