Be ready to have a mess when you do it, but yes you can do it yourself. It takes a while if you do it like I do(I dont know any other way without more tools). Drop the lower radiator hose drain into pan/bucket. Hook it back up fill with water start car let it come up to temp and circulate a couple minutes. Then drain and repeat untill the water you are draining is clear. When you go to refill the radiator mix it a little heavy on the coolant(55/45) side to make up for the water in the block. Then get a tester and make sure it meets the temp specs you need it too. Be careful you will be dealing with a pressurized coolant system that will be hot.
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