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Like many people that posted, I also believe that we will experience some sort of large scale population reduction within the not to distant future. Unlike many posters I don't see us being prepared to survive long term off of our planet within this time frame. There are just too many problems to work out. Plus we don't even know if there are any other livable planets out there, or how to reach them if there is.

Right now we're still blowing up space craft in our own atmosphere. Is it realistic to think that in a couple hundred years we'll be able to master light speed travel and find suitable homes in other solar systems and galaxies? Only if you watch a lot of star wars movies. (EDIT: or robot movies!)

Before (and if) mankind is eliminated he will first be reduced down to much smaller numbers. During this period those people remaining will hardly be able or even concerned with trying to fly to other worlds.

Now let's hear from some optimists!