I have used synthetic oils like Mobil 1 and Castrol in my Mustang GT since it was new. I have 136,000 hard miles on it now and it still doesn't use oil. I change oil every 5k or so, no problem.
I was told that filters like the standard Fram do not have a leak down check valve so you may lose oil pressure when the car sits for awhile. This may cause oil starvation (rattling) when you first start it up. I understand that Purolator or Fram tough guard filters do have that check valve.