Ignition wire goof up

I really messed up the firing order on my 6 cyl 3.2L 1995 Isuzu Trooper (wrong ignition wires to wrong cylinders) and the engine sounds horrible, even as I attempted to reset the wires in order. Did I do some huge damage?

as long as you don't keep running it like that, you didn't

Nope. Just re-route them properly and you'll be fine.