MISFIRE - help, please!

Scanner indicates a "Misfire on Cyl #6".

I tried to isolate the problem by switching with Cyl#5 the sparkplug, then sparkplug wire, then injector. Each time I would do a switch, I would reset the Engine Service light, wait for it to come on then do a reading. Each time the light would come on it would indicate the same message not showing it the problem jumping to Cyl #5.

Since I have determined that the plug, wire, and injector is good in Cyl #6, yet continue to get a misfire, could someone advice on what I else I need to check? I read somewhere that there might be a "vacuum leak". How exactly is that checked?

To check for a vacuum leak you just start the car then spray starter fluid along all vacuum hoses and fittings. Might be worth your while to do a compression check just to rule out any engine damage, but its doubtful that would be the problem.