1985 Fifth Ave: Whining

My uncle has a 1985 Chrysler Fifth Ave. (V8 2 barrel carb) This car has nearly 300,000 miles on it, and aside from interior and exterior appearances, is very reliable. I noticed the other day while riding with him, the car makes a whining type noise while accelarting. My uncle says it's always made this noise, and he has had the car for over 2 years. My question is, is this a normal sound for this particular car? Or should he be concerned this noise is an indication of a problem, even though this is something he noticed over 2 years ago? I appreciate any opinions.

Sorry I failed to mention, the whining noise is coming from the rear of the car.

the whining from the rear sounds like the ring gear and pinion gear have either excessive backlash and/or getting excessively worn. Try replacing the fluid in the rear differential and putting an additive in for posi-type rear ends, that should quiet things down a bit, though not much.

Thanks theFREAKnasty82. I thought it was a transmission issue.