Replacement Tires for Lexus RX300

Can you please provide you opinion on the best replacement tires for my 2000 4WD Lexus RX300. We do almost all local and highway driving. A smooth ride and predictable handling are most important. Its snows occasionally here in the NE and it rains a bit as well, so poor/wet conditions performance is important. We have two little ones, so safety is always a concern. Thanks.