Is it possible

My frind has a super charged 5.0 that he will sell to me for real cheap, but my question is how can i or is it possible to put it in my truck.

yes its possible, my helpful machanical advice is HAVE fun, take everything that makes the moter run, EVERYTHING, fuel pump, all computers, clusters, i doubt the ford stuff will mesh in with gm parts, so you will have to redo everything

If I have time I'll be installing a 5.0L with 5 speed into a S-10 frame this summer (just the frame... for my hotrod)

I'll be taking photo's as I go along. It might be too late to help you out then though