rough idle,low vaccum

I have a rebuilt 350 270 hp engine. Original quadra jet rebuilt and runs rough. Have low vaccum. Help

Wow pretty general. vacuum leaks obviously, valves too tight, timing wrong, for starters.

Do a smoke test to pinpoint any vacuum leaks.

Timing is on, Lifters are adjusted correctly and no vacuum leaks around intake.All vacuum lines are plugged. still have rough idle and can not adjust idle mixture screws

Compression test next. Or short out one wire at a time see if one cylinder does not change the engine speed or roughness.

My 2 cents: Faulty or incorrect PCV valve or hoses. Poor valve seating. Restricted idle passages. Bad coil. This is in addition to everything else mentioned.

Thanks for your 2 cents. All new hoses and pcv, heads where redone and running hei.