It should be 18-23 depending on whether it is driven in the city or on the highway. It's a pretty heavy truck so I wouldn't expect much more than this.
That's a significant improvement from my 2001 Dodge Ram 1500 with the 5.9L, I'm only getting about 10-13 MPG's, with a recent tune-up. I do tow a boat, will the 4.6 do that job ok?