You have to take the truck to the dealer and get the radio programmed for your truck. It can cost anywhere from nothing to 100$ so . Otherwise it fits right in.
I replaced the factory radio in my 07 canyon, and added Sirius. The only tricks are with the chimes and the antenna. If you get a deck from crutchfield, you will get everything needed except the chime box. That is an extra expense, but they do carry it. And unfortunately, the aftermarket harness is connected to that extra part.