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Re: P0300 error code, help please!!
A misfire can happen if there is no spark at all or no spark when it is suppose to fire. A misfire can also happen if there is no fuel in the cylinder when the plug fires.
Your 5.3 has coil packs, so if the coil, plug and wire are working properly, then it makes sense that the injector is bad.
Put a timing light on the #6 wire. It should flash with every spark. If the light does not flash, the coil pack could be bad.
Another trick is to swap the #6 injector with #8 or #4 to see if the misfire follows the injector.
//2000CAYukon
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