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I have a friend who has a 350 in a 92 S-10 pickup (2WD), and he gets (surprisingly) right around 20MPG on the highway with the overdrive trans. City mileage will all depend on how heavy your right foot is. His isn't light, and the rear tires never last long. : )
Someday when the old "Iron Duke" in my S-10 dies, I plan on hacking something a bit larger in there.
I'm sure a blazer would be about the same, except for the 4WD gear.
There's a book out there called "S-10 V8 conversions" or something to that effect - I'd recommend it. Might save you some time, money, and bloody knuckles.
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