Ok first off, this wire, you said "it was bolted to the frame" and you "don't know where it origionated", didn't it come from the frame like you said? if it did and you just can't find the hole, just make a new one....this is likely your ground wire for your fuel pump/sender....secondly, you said you "can't tell if the fuel pump is running" so your truck won't start now or?? if it won't start then i would definitly say the wire is your ground source. So basically this is what i would do....attach the wire to the frame (if one end is currently attached to the pump) i had a blazer and i did replace the tank once, i think all i remember is the plug that goes into the pump/sender unit and then it goes into a harness. So i may not have helped at all, i guess what i'm gettig at is that if your fuel gauge and pump are not working then it is likely the ground wire for the circuit, just attach it to either the frame or sender unit. Hope that did something for you, if not try and describe it better and i'll give it another go!