Hmmm...
Well, both are obivously magnificent pieces of machinery. The inline six used in the Skyline has proved to be a very versatile and coveted engine in the automobile world. It can be boosted to throw lots of power to the flywheel, and in the Skyline it makes one of the most dominating sports cars produced in Japan (especially those tuned by Tommy Kaira!).
However, I am heavily biased towards Honda, so I like the NSX. Yes, it does cost quite a bit more, but its mid-engined layout provides exceptional handling prowess, keeping the powerplant close to the power wheels. And it is a much more exclusive, exotic-looking car.
I will admit that I wanted one of the two just to take to performance exrtremes, heighten the boost levels, and drive to the limit, I would prefer to have a Skyline.