87 b2600 dies at full throttle

I have a 87 b2600 with a holley 5200 carb in place of orig. I have a problem with it sputtering and dying at full throttle at higher rpm under load. If you lift, it will stay running and idle fine. At hiway speeds if it does it you can turn off key and turn it back on and restart. After doing this it will run fine until you go to full throttle at higher rpm again. Have replaced module in distibutor and coil, new plug wires and plugs. Acts like it is fuel related (like its running out of gas) but with the turning key off and on I thought it was electrical. please help.

check/replace the fuel filter. My 83 had almost the same problem and changing the fuel filter fixed it.

if your catalytic converters are still there, you might want to get them checked...