If i were to get hondata for a crx w/ JRSC would i still need to adjust things like fuel pressure with my FPR or timing with the MSD boost timing master or will hondata take care of all that stuff. Will i need bigger injectors to run Hondata?

you still need to adjust them manually, and bigger injectors prolly arent required to run the hondata, but they will greatly benefit that SC setup you got.